THE EFFECT OF HIGH INTENSITY INTERVAL TRAINING AND THYME EXTRACT ON OXIDATIVE STRESS AND ANTIOXIDATIVE FACTORS IN DIABETIC RATS

of obesity and inactive physical activity, and glucose modulation is of great importance in these individuals. Thyme was studied on type 2 diabetic rats by streptozotocin and high fat diet. Methods: Male Wistar rats weighing 110±10 g were used in this study. The rats were randomly divided into four groups of Thymus + Exercise, Thymus, Exercise and Control groups. The extract was taken 200 g daily through a gavage syringe. Exercise included: Running on a treadmill at a speed of at least 20 m / min and a maximum of 38 m / min for 60 minutes daily, 5 days a week, for 8 weeks. Serum malondialdehyde (MDA), glutathione peroxidase (GTX), superoxide dismutase (SOD), catalase (CAT) were measured by ELISA method. Results: Serum MDA and CAT levels were significantly higher in the control group (p = 0.002). The results also showed that there was no significant difference between SOD and GPX levels in different research groups (p = 0.790). Conclusion: Intermittent exercise (HIIT) and thyme extract can improve oxidative and antioxidant balance in diabetic rats.